George and Harold are up to their usual tricks. Last time they hypnotized Principal Krupp into believing he was Captain Underpants. Now, by mistake, they bring to life the most disgusting, life-threatening monster — the terrible Turbo Toilet 2000. Can anyone save the school from the terrifying attack of the Talking Toilets? Watch out world, big briefs are back!Principal Krupp once again turns into the superhero Captain Underpants in order to save the world, and Jerome Horwitz Elementary School, from the evil talking toilets and the Turbo Toilet 2000.